old_syllabus.md

1. Mendelian Inheritance

Reading: Chapter 2

1. Independent Assortment

Reading: Chapter 3

1. Gene Interaction

Reading: Chapter 6

1. Genetic Mapping

Reading: Chapter 4

1. Quantitative Genetics

Reading: Chapter 19

1. Population Genetics

Reading: Chapter 18

1. Phylogenetics

Reading: Chapters 14, 20

1. Chromosomal Evolution

Reading: Chapter 17

1. Case Study: tb1

Reading: Studer et al. 2011 Nature Genetics

Phenotype
- phenotype in teosinte
- phenotype in maize
- causative mutation in teosinte
- multiple alleles and effects

Mapping
- mode of action
- complementation
- QTL
- fine mapping

Popgen
- selection on tb1
- standing variation in teosinte
- introgression

Phylogenetics
- role in other grasses
- orthology etc.

1. DNA

Reading: Chapter 7

1. Mutation & recombination

Reading: Chapter 16

1. RNA

Reading: Chapter 8

1. Control of Gene Expression

Reading: Chapters 11, 12

1. Proteins

Reading: Chapter 9

1. Transposable Elements

Reading: Chapter 15

1. Gene Isolation and Manipulation

Reading: Chapter 10

1. Development

Reading: Chapter 13

1. Forward and Reverse Genetics

2. Genomics

   Possible Reading: Slatkin HWE paper?

Reading: Chapter 14

1. Case Study: tb1

   Forward genetics

   • TE tagging
     • this is how went from QTL -> gene

   Reverse Genetics

   • transformation
     • proof tb1 is the locus
   • enhancer bashing
     • proof Hopscotch is causative

   Development

   Pathway

Notes

Do stickleback for second case study?