Is celltypist suitable for predicting mouse immune types？

[ttt-404]

Thank you for your amazing tool, but I wonder if “Immune_All_High/Low” models are suitable for predicting cell types in mouse data? I tried to do so, but only a few cell types (only 4/5 types) were provided, I wonder what's wrong...
Thank you for your time if you can provide any information about this!

[ChuanXu1]

@ttt-404, the immune model is from human, so very few genes are overlapped with your mouse data.

You can convert the human model to mouse one, and then apply CellTypist using the new model.

model = celltypist.Model.load('Immune_All_Low.pkl')
model.convert()
model.write('transformed_mouse_immune_model.pkl')
celltypist.annotate(your_adata, model = 'transformed_mouse_immune_model.pkl', majority_voting = True)

The result should be interpreted with caution due to inter-species difference.

[Lucyyang1991]

Do you plan to add mouse immune model, but not convert human immune model into mouse one?