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cascade_1.0.sif
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CASP3 -> Antisurvival
FOXO_f -> Antisurvival
CASP8 -> CASP3
CASP9 -> CASP3
AKT_f -| FOXO_f
NLK -| FOXO_f
CCND1 -> Prosurvival
MYC -> Prosurvival
TCF7_f -> CCND1
RSK_f -> CCND1
TCF7_f -> MYC
mTORC2_c -> RAC_f
DVL_f -> RAC_f
TSC_f -> mTORC2_c
S6K_f -| mTORC2_c
FZD_f -> DVL_f
RAC_f -> MAP3K4
RAC_f -> MAP3K11
MAP3K4 -> MAP2K4
MAP3K11 -> MAP2K4
MAP3K7 -> MAP2K4
GRAP2 -> MAP2K4
TAB_f -> MAP3K7
MAPK14 -| GRAP2
MAP3K7 -> MAP2K7
GRAP2 -> MAP2K7
MAP2K7 -> JNK_f
MAP2K4 -> JNK_f
DUSP1 -| JNK_f
MAPK14 -> DUSP1
MSK_f -> DUSP1
MAP2K3 -> MAPK14
MAP2K4 -> MAPK14
DUSP1 -| MAPK14
MAP3K7 -> MAP2K3
MAP3K5 -> MAP2K3
AKT_f -| MAP3K5
PDPK1 -> AKT_f
mTORC2_c -> AKT_f
MAPK14 -| TAB_f
MAPK14 -> MSK_f
ERK_f -> MSK_f
MMP_f -> RTPK_f
RTPK_g -> RTPK_f
MAPK14 -| RTPK_f
MEK_f -| RTPK_f
FOXO_f -> RTPK_g
RAF_f -> MEK_f
MAP3K8 -> MEK_f
ERK_f -| MEK_f
RTPK_f -> SHC1
PTEN -| SHC1
PTEN_g -> PTEN
GSK3_f -| PTEN
SHC1 -> GRB2
GRB2 -> SOS1
ERK_f -| SOS1
MEK_f -> ERK_f
DUSP6 -| ERK_f
SOS1 -> KRAS
PTPN11 -> KRAS
GAB_f -> PTPN11
KRAS -> RAF_f
AKT_f -| RAF_f
ERK_f -| RAF_f
RHEB -| RAF_f
TSC_f -| RHEB
IKBKB -> MAP3K8
ERK_f -> DUSP6
mTORC1_c -> DUSP6
RSK_f -> mTORC1_c
RHEB -> mTORC1_c
AKT1S1 -| mTORC1_c
GRB2 -> GAB_f
ERK_f -| GAB_f
ERK_f -> RSK_f
PDPK1 -> RSK_f
PIK3CA -> PDPK1
PTEN -| PDPK1
GAB_f -> PIK3CA
IRS1 -> PIK3CA
KRAS -> PIK3CA
S6K_f -| IRS1
ERK_f -| IRS1
IKBKB -| IRS1
PDPK1 -> S6K_f
mTORC1_c -> S6K_f
MAP3K7 -> IKBKB
TP53 -| IKBKB
EGR1 -> PTEN_g
LRP_f -| GSK3_f
RSK_f -| GSK3_f
S6K_f -| GSK3_f
ERK_f -| GSK3_f
MAPK14 -| GSK3_f
DVL_f -| GSK3_f
AKT_f -| GSK3_f
GSK3_f -> TSC_f
IKBKB -| TSC_f
AKT_f -| TSC_f
RSK_f -| TSC_f
ERK_f -| TSC_f
MAPK14 -> TP53
MDM2 -| TP53
AKT_f -| AKT1S1
AKT_f -> MDM2
MDM2_g -> MDM2
S6K_f -| MDM2
NFKB_f -> MDM2_g
TP53 -> MDM2_g
TP53 -> BAX
BAX -> CYCS
BCL2 -| CYCS
BAD -| BCL2
AKT_f -| BAD
RSK_f -| BAD
MAP3K7 -> NLK
CYCS -> CASP9
CFLAR -| CASP8
AKT_f -> CFLAR
ITCH -| CFLAR
JNK_f -> ITCH
SFRP1 -| FZD_f
SFRP1_g -> SFRP1
FZD_f -> LRP_f
ERK_f -> LRP_f
JNK_f -> LRP_f
MAPK14 -> LRP_f
DKK_f -| LRP_f
DKK_g -> DKK_f
LRP_f -| AXIN1
LRP_f -| CK1_f
AXIN1 -> BTRC
GSK3_f -> BTRC
CK1_f -> BTRC
CHUK -> CTNNB1
BTRC -| CTNNB1
AKT_f -> CHUK
CTNNB1 -> TCF7_f
NLK -| TCF7_f
TCF7_f -| EGR1
TCF7_f -> DKK_g
MYC -| DKK_g
MYC -| SFRP1_g
CHUK -> NFKB_f
IKBKB -> NFKB_f
MSK_f -> NFKB_f
CTNNB1 -> LEF
LEF -> MMP_f