diff --git a/ImageSymmetricCenter.m b/ImageSymmetricCenter.m
index 901c593..2a0f1ac 100644
--- a/ImageSymmetricCenter.m
+++ b/ImageSymmetricCenter.m
@@ -2,7 +2,7 @@
 % FindSymmetricCenter runs an optimization to find the pixel coordinates 
 % around which a 2D image is most symmetric. It returns two variables, a 
 % [2 x 1] vector of center coordinates and a [n x 1] array representing the
-% mean radial profile from the center coordinate to the edge of the
+% median radial profile from the center coordinate to the edge of the
 % image.
 %
 % Example usage:
@@ -26,7 +26,7 @@
 % with this program. If not, see http://www.gnu.org/licenses/.
 
 % Define number of rays to average and initialize profile/profiles arrays
-rays = 32;
+rays = 128;
 profile = zeros(max(size(image)), 1);
 profiles = zeros(max(size(image)), rays);
 
diff --git a/OptimizeCorrection.m b/OptimizeCorrection.m
new file mode 100644
index 0000000..506e6bf
--- /dev/null
+++ b/OptimizeCorrection.m
@@ -0,0 +1,73 @@
+function [center, corrected] = OptimizeCorrection(radial, image, res)
+% OptimizeCorrection calculates an optimized radial profile correction
+% based on a target radial profile and source image.
+%
+% Author: Mark Geurts, mark.w.geurts@gmail.com
+% Copyright (C) 2022 Aspirus, Inc.
+%
+% This program is free software: you can redistribute it and/or modify it 
+% under the terms of the GNU General Public License as published by the  
+% Free Software Foundation, either version 3 of the License, or (at your 
+% option) any later version.
+%
+% This program is distributed in the hope that it will be useful, but 
+% WITHOUT ANY WARRANTY; without even the implied warranty of 
+% MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the GNU General 
+% Public License for more details.
+% 
+% You should have received a copy of the GNU General Public License along 
+% with this program. If not, see http://www.gnu.org/licenses/.
+
+% Start optimization at center of target image
+center = size(image)/2 + 0.5;
+
+% Normalize image to 1.000 at center
+image = image / image(ceil(center(1)), ceil(center(2)));
+
+% Normalize radial to 1.000 at origin
+radial(:,2) = radial(:,2) / radial(1,2);
+
+% Initialize corrected radial x and y values
+n = 15;
+x = (0:1/(n-1):1)'*radial(end,1);
+y = ones(length(x)-1, 1);
+
+% Display progress dialog
+d = waitbar(0, 'Optimizing calibration correction');
+p = 0;
+
+% Run optimization
+options = optimset('Display', 'final', 'MaxFunEvals', n*100+1000, 'MaxIter', n*100);
+vars = [center, y'];
+vars = fminsearch(@objectiveFunction, vars, options);
+center = vars(1:2);
+corrected = [x, [1 vars(3:end)]'];
+
+% Clean up
+close(d);
+clear d p n;
+
+% Define optimization function
+function f = objectiveFunction(c)
+
+    % Update waitbar
+    p = p + 1/(n*100);
+    waitbar(min(p,1), d);
+
+    % Calculate radial coordinates of image pixels
+    r = sqrt(((repmat(1:size(image,2), [size(image,1) 1]) - c(2)) * res(2)) .^ 2 + ...
+        ((repmat(1:size(image,1), [size(image,2) 1])' - c(1)) * res(1)) .^ 2);
+
+    % Apply correction to radial profile
+    cr = radial(:,2) .* interp1(x, [1 c(3:end)], radial(:,1), 'linear', 1);
+    
+    % Objective is difference between image and corrected profile
+    f = sum(sum((interp1(radial(:,1), cr, r, 'linear', 0) - image) .^ 2));
+
+end
+
+% End main function
+end
+
+
+    
diff --git a/PDProfiler.mlapp b/PDProfiler.mlapp
index d45646a..ede5ddb 100644
Binary files a/PDProfiler.mlapp and b/PDProfiler.mlapp differ