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Interdocker is an experimental machine learning pipeline to dock protein structures

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AllanSCosta/InterDocker

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InterDocker: Iterative Structure-Based Protein Docking

Architecture

Documentation coming soon!

Poster: Learning Meaningful Representations of Life

Encoding

Cross-Encoding

Docking

Dependencies

This repository integrates a number of codebases into a protein-protein docking system.

IPA and MPNerf are present as submodules, as they are modified from original.

Data Processing

The file data_preprocess.py will set up data for training. The steps are as follows

  • Download LMDBs from Atom3D
  • Map LMDBs to separated PDB chains
  • Parse PDBs into SidechainNet format, unify data into single files
  • Extract and encode sequences from PDB through ESM
  • Wrap dataset into single SidechainNet Dataset format

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Interdocker is an experimental machine learning pipeline to dock protein structures

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