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PeacthAC
 
 
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README.md
README.md
 
 
manage.py
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Run Peacth-AC API

Instalar requerimientos

pip install -r requirements.txt

Se requiere tener una base de datos en mongoDB

use peacth-ac

Borrar "0001_initial.py"

python3 manage.py makemigrations api
python3 manage.py migrate

Documentación API

API root

ESTIMACIÓN DE DOSIS

Calcular dosis semanal [POST]

This method calculate the dose of the patients, but it doesn't save the patient in the database

  • patients/get_weekly_dosis/
  • Request (application/JSON)
    • Body
    {
		"code": "T-001",             
		"sex": "M",                  
		"initialDate": "2009-11-30", 
		"initialDose": 0,  # Always 0        
		"initialINR": 1.1,           
		"weeklyDoseInRange": 0, # Always 0   
		"totalDays": 534, 	     
		"weight": 80.0, 	     
		"height": 1.68, 	     
		"imc": 28.3,                
		"age": 69,                   
		"genetics": {
			"CYP2C9_2": "*1/*1", 
			"CYP2C9_3": "*1/*1", 
			"VKORC1": "A/A"      
		}
}
  • Response (application/JSON) 
     {
 	"regressionDose": 5.742530690407449,
 	"networkDose": 5.193664073944092
 }

Fijar dosis [POST]

This method set the dose of the patients and saves it to the database

  • patients/set_dose/
  • Request (application/JSON)
    • Body
    {
		"code": "T-001",             
		"sex": "M",                  
		"initialDate": "2009-11-30", 
		"initialDose": 6.0,   # With the chosen dose       
		"initialINR": 1.1,           
		"weeklyDoseInRange": 0,   # Always 0 
		"totalDays": 534, 	     
		"weight": 80.0, 	     
		"height": 1.68, 	     
		"imc": 28.3,                
		"age": 69,                   
		"genetics": {
			"CYP2C9_2": "*1/*1", 
			"CYP2C9_3": "*1/*1", 
			"VKORC1": "A/A"      
		}
}
  • Response (application/JSON) 
     {
 	"message" : "Dosis fijada correctamente.",
 	"initialDose": 5.742530690407449
 }

Ver un paciente [GET]

This method obtains the info of a pacient with a code

  • patients/{code}
  • Response 
    {
		"code": "T-001",             
		"sex": "M",                  
		"initialDate": "2009-11-30", 
		"initialDose": 6.0,          
		"initialINR": 1.1,           
		"weeklyDoseInRange": 10.0,   
		"totalDays": 534, 	     
		"weight": 80.0, 	     
		"height": 1.68, 	     
		"imc": 28.3,                
		"age": 69,                   
		"genetics": {
    		"CYP2C9_2": "*1/*1", 
			"CYP2C9_3": "*1/*1", 
			"VKORC1": "A/A"      
		}
}

Análisis Genético [GET] (Sujeto a Cambio)

  • patients/T-001/genetic_analysis/
  • Response (application JSON) 
     {
 	"CYP2C9": {
 		"CYP2C9*2": "Heterocigoto",
 		"CYP2C9*3": "Heterocigoto",
 		"resp": "El genotipo del paciente corresponde a un metabolizador intermedio (IM)"
 	},
 	"VKORC1": {
 		"Alelo": "Doble mutado (A/A)",
 		"resp": "El genotipo del paciente se relaciona con una menor dosis de Acenocumarol"
 	}
 }

Perfil del paciente

  • patients/{code}/patient_profile/
  • Response (application JSON) 
     {
 	"clinic": {
 		"_id": "60f1ec92e7be8e6f7e378c16",
 		"code": "T-003",
 		"sex": "M",
 		"initialDate": "2009-01-19",
 		"initialDose": 12.0,
 		"initialINR": 2.0,
 		"weeklyDoseInRange": 10.0,
 		"totalDays": 94,
 		"weight": 0.0,
 		"height": 0.0,
 		"imc": 0.0,
 		"age": 64,
 		"genetics": {
 			"CYP2C9_2": "*1/*1",
 			"CYP2C9_3": "*1/*1",
 			"VKORC1": "A/A"
 		}
 	},
 	"genetic": {
 		"CYP2C9": {
 			"rs1799853": "Ausente",
 			"rs1057910": "Ausente",
 			"Observaciones": "El genotipo del paciente corresponde a un metabolizador extensivo o silvestre (EM)"
 		},
 		"VKORC1": {
 			"rs9923231": "Doble mutado (A/A)",
 			"Observaciones": "El genotipo del paciente se relaciona con una menor dosis de Acenocumarol"
 		}
 	}
 	"historicINR": {
 		"dates": [
 			"30/11/2009",
 			"30/12/2009",
 			"30/01/2010",
 			"30/03/2010"
 		],
 		"inrValues": [
 			3.4,
 			3.7,
 			3.2,
 			3.0
 		],
 		"doseValues": [
 			0,
 			66.0,
 			50.0,
 			40.0
 		]
 	}
 }

Registra visitas

Ver todos los controles registrados [GET]

This method allows us to see all the information about medical checks.

  • clinical_control/
  • Response (application JSON) 
     { 
 	"_id":  "60f1e93f08956a1ceb4ffb5a",  
 	"patientCode":  "T-999",  
 	"controlDate":  "2009-11-30",  
 	"arrivalDose":  0.0,  
 	"updatedDose":  9.929399471052776,  
 	"arrivalINR":  1.1,  
 	"inrInRange":  false
 }

Registrar visita [POST]

This method save the information about patient's medical checks

  • clinical_control/register_visit/
  • Request (application/JSON)
    • Body 
         {   
 	  "patientCode":  "T-999",  
 	  "controlDate":  "2009-11-30",  
 	  "arrivalDose":  0.0,  
 	  "updatedDose":  9.929399471052776,  
 	  "arrivalINR":  1.1,  
 	  "inrInRange":  false  
 	}
  • Response (application/JSON) 
     { 
 	"message": "Saved Succesfully"
 }

Obtener última visita de un paciente [GET]

  • clinical_control/{patientCode}/get_last/
  • Response (application/JSON) 
     {
 	"_id": "61a4492543dcb6d6e9221657",
 	"patientCode": "Q-001",
 	"controlDate": "2010-03-28",
 	"arrivalDose": 11.0,
 	"updatedDose": 12.0,
 	"arrivalINR": 2.5,
 	"inrInRange": false
 }

Actualizar parámetros del algoritmo

Actualizar parámetros de forma manual [POST]

This method allow us change the current parameters of the pharmacogenetics algorithm

  • LogWTDparameters/set_parametres/set_parametres/
  • Request (application/JSON)
    • Body 
       {  
 	"p_0":  3.081,  
 	"p_men":  0.167,  
 	"p_age":  0.0081,  
 	"p_initialINR":  0.055,  
 	"p_imc":  0.013, 
 	"p_CYP2C9_12":  0.107,  
 	"p_CYP2C9_13":  0.323,  
 	"p_CYP2C9_33":  0.746,  
 	"p_VKORC1_GA":  0.27,  
 	"p_VKORC1_AA":  0.701,
 	"r_squared": 0.5147  
 }
  • Response (application/JSON) 
     { 
 	"message": "Parametres updated Succesfully"
 }

Obtener la última actualización de los parámetros [GET]

This method allow us change the current parameters of the pharmacogenetics algorithm

  • LogWTDparameters/get_last/get_last
  • Response (application/JSON) 
     {
 	"_id": "60f1ee881f69782bda74a492",
 	"p_0": 3.081,
 	"p_men": 0.167,
 	"p_age": 0.0081,
 	"p_initialINR": 0.055,
 	"p_imc": 0.013,
 	"p_CYP2C9_12": 0.107,
 	"p_CYP2C9_13": 0.323,
 	"p_CYP2C9_33": 0.746,
 	"p_VKORC1_GA": 0.27,
 	"p_VKORC1_AA": 0.701,
 	"r_squared": 0.5147
 }

Regresión lineal [GET]

  • LogWTDparameters/multivariable_regression/
  • Response (application/JSON) 
     {
 	"message": "Los parámetros no se actualizaron debido a que el r2 es menor a la regresión actual",
 	"params": {
 		"p_0": 4.8519927925716475,
 		"p_men": 0.22211275448247525,
 		"p_age": -0.012814841488389746,
 		"p_initialINR": -0.0784394288974603,
 		"p_imc": 0.008287360486787231,
 		"p_CYP2C9_12": -0.17796969096743442,
 		"p_CYP2C9_13": -0.45815491317751467,
 		"p_CYP2C9_33": -1.1406527502812869,
 		"p_VKORC1_GA": -0.418752414756341,
 		"p_VKORC1_AA": -1.0545597169772143,
 		"r_squared": 0.5116452670520679
 	}
 }

Comparación de modelos

  • models_analysis/
  • Response (application/JSON) 
     [
 	{
 		"_id": "61a2c16a323df109b65afde1",
 		"code": "T-001",
 		"network_result": 9.929399471052776,
 		"regression_result": 9.107564926147461,
 		"network_error": 0.08924350738525391,
 		"regression_error": 0.007060052894722446,
 		"final_dose": 10.0,
 		"is_treatement_done": true
 	},
 	{
 		"_id": "61a2c16b323df109b65afde2",
 		"code": "T-002",
 		"network_result": 11.289803802260646,
 		"regression_result": 8.968988418579102,
 		"network_error": 0.5017228656344943,
 		"regression_error": 0.3727886776521863,
 		"final_dose": 18.0,
 		"is_treatement_done": true
 	},
 	{
 		"_id": "61a2c16c323df109b65afde3",
 		"code": "T-003",
 		"network_result": 6.81141580885468,
 		"regression_result": 11.417252540588379,
 		"network_error": 0.1417252540588379,
 		"regression_error": 0.31885841911453194,
 		"final_dose": 10.0,
 		"is_treatement_done": true
 	},
 	...
 ]

Análisis comparativo de la dosis calculada entre genotipos ingresados

  • Parameters + gen (string) : the gene for which information is required

Información boxplot [GET]

This method get information needed to plot boxplot

  • distributions/boxplot/{gen}
  • Response (application/JSON) 
     [
 	{
 		"label": "A/A",
 		"value": [
 			-0.75,
 			6.0,
 			8.0,
 			10.5,
 			17.25
 		]
 	},
 	{
 		"label": "G/A",
 		"value": [
 			0.5,
 			11.0,
 			13.25,
 			18.0,
 			28.5
 		]
 	},
 	{
 		"label": "G/G",
 		"value": [
 			2.0,
 			14.0,
 			18.0,
 			22.0,
 			34.0
 		]
 	}
 ]

Información distribución [GET]

This methos get information for distribution plots

  • distributions/frequency/{gen}
  • Response (application/JSON) 
     {
 	"labels": [
 		"G/A",
 		"G/G",
 		"A/A"
 	],
 	"frequency": [
 		154,
 		84,
 		65
 	]
 }

Red neuronal

Entrenar Red Neuronal [GET]

This method trains the neural network

  • LogWTDparameters/neural_network
  • Response (application/JSON) 
     {
 	"is_updated" : True,
 	"loss": "9.88%",
 	"updated_at_at": "27/10/2021 01:16:50"
 	"message": "Red neuronal actualizada."
 }

Obtener último modelo de la Red Neuronal [GET]

This method trains the neural network

  • LogWTDparameters/get_last_neural_network/
  • Response (application/JSON) 
     {
 	"loss": "9.88%",
 	"created_at": "27/10/2021 01:16:50"
 }

Enviar email [POST]

This method send an email to some addressee

  • api/send_email/
  • Request (application/JSON)
    • Body
    {
	"email": "[email protected]",
	"totalDosis" : 1,
	"patient" : "T-001"            
}
  • Response (application/JSON) 
     {
 	'response' : 'correo enviado con exito'
 }

Registro

Médicos [POST]

  • api/medical/register/
  • Request (application/JSON)
    • Body
    {
	"email": "[email protected]",
	"password": "test",
	"name": "Cosme",
	"last_name": "Fulanito",
	"registry_number": "1234",
	"rut": "12345678-9"
}
  • Response (application/JSON) 
     {
 	"_id": "61a6a1c0b9ba261409f0f662",
 	"email": "[email protected]",
 	"name": "Cosme",
 	"last_name": "Fulanito",
 	"registry_number": "123456",
 	"rut": "12345678-9"
 }

Laboratoristas [POST]

  • api/laboratory_worker/register/
  • Request (application/JSON)
    • Body
    {
	"email": "[email protected]",
	"password": "test",
	"name": "Cosme",
	"last_name": "Fulanito"
}
  • Response (application/JSON) 
     {
 	"_id": "61a6a261b9ba261409f0f663",
 	"email": "[email protected]",
 	"password": "test",
 	"name": "Cosme",
 	"last_name": "Fulanito"
 }

Login

Médicos [POST]

  • api/medical/login/
  • Request (application/JSON)
    • Body
    {
	"email": "[email protected]",
	"password": "test"
}
  • Response (application/JSON) 
     {
 	"jwt": "eyJ0eXAiOiJKV1QiLCJhbGciOiJIUzI1NiJ9.					eyJydXQiOiIxMjM0NTY3OC05IiwibmFtZSI6IkNvc21lIiwibGFzdF9uYW1lIjoiRnVsYW5pdG8iLCJ0eXBlIjoibWVkaWNhbF9zdGFmZiJ9.vK2ikOEAIBVr3y2ufI4cTXPTF3H3BYGkWlTnHJAWkmY"
 }

Laboratoristas [POST]

  • api/laboratory_worker/login/
  • Request (application/JSON)
    • Body
    {
	"email": "[email protected]",
	"password": "test"
}
  • Response (application/JSON) 
     {
 	"jwt": "eyJ0eXAiOiJKV1QiLCJhbGciOiJIUzI1NiJ9.					eyJydXQiOiIxMjM0NTY3OC05IiwibmFtZSI6IkNvc21lIiwibGFzdF9uYW1lIjoiRnVsYW5pdG8iLCJ0eXBlIjoibWVkaWNhbF9zdGFmZiJ9.vK2ikOEAIBVr3y2ufI4cTXPTF3H3BYGkWlTnHJAWkmY"
 }

Logout

Médicos [POST]

  • api/medical/logout/
  • Response (application/JSON) 
     {
 	"message": "Logout success"
 }

Laboratoristas [POST]

  • api/laboratory_worker/logout/
  • Response (application/JSON) 
     {
 	"message": "Logout success"
 }

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Tecnologías

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  • Heroku, MongoDB Atlas Database
  • React, PrimeReact, Apexcharts

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