Pyramidal tract neurons and Parkinson’s disease in simulated mouse primary motor cortex
Pyramidal tract neurons are the most direct output to muscles from the primary motor cortex (M1). Liqiang Chu et al (2021) have shown that layer 5 pyramidal tract neurons (PT5B) decrease in excitability in parkinsonian as compared with control M1 in mice treated with 6-OHDA. We built this simulation, based on a detailed motor cortex implementation in NetPyNE, to see how the changed PT5B neuron excitability changes M1 spiking dynamics.
NetPyNE is a Python package for creating biological neural networks using the NEURON simulator.
Get the preprint Donald W. Doherty et al. (2024).
Acknowlegements
This research was funded by Aligning Science Across Parkinson's [ASAP-020572] through the Michael J. Fox Foundation for Parkinson's Research (MJFF).