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@article {Guidolin2024,
author = {Guidolin, Carolina and Aerts, Sam and Agbeshie, Gabriel Kwaku and Akuffo, Kwadwo Owusu and Aydin, Sema Nur and Baeza Moyano, David and Bolte, John and Broszio, Kai and Cantarero-Garc{\'\i}a, Guadalupe and Didikoglu, Altug and Gonz{\'a}lez-Lezcano, Roberto Alonso and Joosten-Ma, Hongli and Melero-Tur, Sofia and Nilsson Tengelin, Maria and P{\'e}rez Guti{\'e}rrez, Mar{\'\i}a Concepci{\'o}n and Stefani, Oliver and Svensson, Ingemar and Udovicic, Ljiljana and Zauner, Johannes and Spitschan, Manuel},
title = {Protocol for a prospective, multicentre, cross-sectional cohort study to assess personal light exposure},
elocation-id = {2024.02.11.24302663},
year = {2024},
doi = {10.1101/2024.02.11.24302663},
publisher = {Cold Spring Harbor Laboratory Press},
abstract = {Light profoundly impacts many aspects of human physiology and behaviour, including the synchronization of the circadian clock, the production of melatonin, and cognition. These effects of light, termed the non-visual effects of light, have been primarily investigated in laboratory settings, where light intensity, spectrum and timing can be carefully controlled to draw associations with physiological outcomes of interest. Recently, the increasing availability of wearable light loggers has opened the possibility of studying personal light exposure in free-living conditions where people engage in activities of daily living, yielding findings associating aspects of light exposure and health outcomes, supporting the importance of adequate light exposure at appropriate times for human health. However, comprehensive protocols capturing environmental (e.g., geographical location, season, climate, photoperiod) and individual factors (e.g., culture, personal habits, behaviour, commute type, profession) contributing to the measured light exposure are currently lacking. Here, we present a protocol that combines smartphone-based experience sampling (experience sampling implementing Karolinska Sleepiness Scale, KSS ratings) and high-quality light exposure data collection at three body sites (near-corneal plane between the two eyes mounted on spectacle, neck-worn pendant/badge, and wrist-worn watch-like design) to capture daily factors related to individuals{\textquoteright} light exposure. We will implement the protocol in an international multi-centre study to investigate the environmental and socio-cultural factors influencing light exposure patterns in Germany, Ghana, Netherlands, Spain, Sweden, and Turkey (minimum n=15, target n=30 per site, minimum n=90, target n=180 across all sites). With the resulting dataset, lifestyle and context-specific factors that contribute to healthy light exposure will be identified. This information is essential in designing effective public health interventions.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThe project (22NRM05 MeLiDos) has received funding from the European Partnership on Metrology, co-financed by the European Union{\textquoteright}s Horizon Europe Research and Innovation Programme and by the Participating States. Further finding is provided by the TUM Global Incentive Fund (GIF0000031) to support the collaboration between TUM and KNUST, and TUBITAK - The Scientific and Technological Research Council of Turkiye (Grant no. 224S740).Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:This research protocol was reviewed and approved by the Medical Ethics Committee of the Technical University of Munich (2023-115-S-KK).I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).YesI have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable.YesUpon conclusion of the primary analyses, the data will be made available under the Creative Commons license (CC-BY) with no reservations in the supplementary material of the research publication and/or on a public repository (e.g., FigShare).},
URL = {https://www.medrxiv.org/content/early/2024/09/26/2024.02.11.24302663},
eprint = {https://www.medrxiv.org/content/early/2024/09/26/2024.02.11.24302663.full.pdf},
journal = {medRxiv}
@article{biller2024,
author = {Biller, Anna M. and Fatima, Nayab and Hamberger, Chrysanth and Hainke, Laura and Plankl, Verena and Nadeem, Amna and Kramer, Achim and Hecht, Martin and Spitschan, Manuel},
title = {The Ecology of Human Sleep (EcoSleep) Cohort Study: Protocol for a longitudinal repeated measurement burst design study to assess the relationship between sleep determinants and outcomes under real-world conditions across time of year},
journal = {Journal of Sleep Research},
pages = {e14225},
year = {2024},
doi = {10.1111/jsr.14225},
url = {https://onlinelibrary.wiley.com/doi/abs/10.1111/jsr.14225},
eprint = {https://onlinelibrary.wiley.com/doi/pdf/10.1111/jsr.14225},
keywords = {individual sleep differences, naturalistic conditions, photoperiod, prospective cohort study, season, sleep architecture, sleep variability},
}

@article{devries2024,
author = {de Vries, SW and Gkaintatzi-Masouti, M and van Duijnhoven, J and Mardaljevic, J and Aarts, MPJ},
title = {Recommendations for light-dosimetry field studies based on a meta-analysis of personal light levels of office workers},
journal = {Lighting Research \& Technology},
volume = {55},
pages = {14771535241248540},
doi = {10.1177/14771535241248540},
month = {May},
year = {2024}
}

@article{guidolin2024,
author = {Guidolin, Carolina and Aerts, Sam and Agbeshie, Gabriel Kwaku and Akuffo, Kwadwo Owusu and Aydin, Sema Nur and Baeza Moyano, David and Bolte, John and Broszio, Kai and Cantarero-Garc{\'\i}a, Guadalupe and Didikoglu, Altug and Gonz{\'a}lez-Lezcano, Roberto Alonso and Joosten-Ma, Hongli and Melero-Tur, Sofia and Nilsson Tengelin, Maria and P{\'e}rez Guti{\'e}rrez, Mar{\'\i}a Concepci{\'o}n and Stefani, Oliver and Svensson, Ingemar and Udovicic, Ljiljana and Zauner, Johannes and Spitschan, Manuel},
title = {Protocol for a prospective, multicentre, cross-sectional cohort study to assess personal light exposure [preprint]},
journal = {medRxiv},
year = {2024},
elocation-id = {2024.02.11.24302663},
doi = {10.1101/2024.02.11.24302663},
}

@article{SPITSCHAN2024114909,
title = {Illuminating the future of wearable light metrology: Overview of the MeLiDos Project},
journal = {Measurement},
volume = {235},
pages = {114909},
year = {2024},
issn = {0263-2241},
doi = {https://doi.org/10.1016/j.measurement.2024.114909},
url = {https://www.sciencedirect.com/science/article/pii/S0263224124007942},
author = {Manuel Spitschan and Johannes Zauner and Maria {Nilsson Tengelin} and Constantinos A. Bouroussis and Patrik Caspar and Fabien Eloi},
abstract = {Light exposure profoundly influences human health, regulating circadian rhythms and impacting wakefulness and sleepiness. Estimating the effects of light exposure under everyday conditions requires personal, wearable light logging and dosimetry approaches. This article introduces the MeLiDos Project (2023–2026), supported by the European Association of National Metrology Institutes (EURAMET). The project's first branch defines quality indices and calibration standards for wearable light loggers, adapting existing metrological standards to their smaller size and distinct purpose in the field rather than the laboratory. The second branch develops a software ecosystem, including the open-source R software package LightLogR, designed to manage the increasing volume of data, ensuring reusability, accessibility and interoperability of data. The third branch explores the potential of spatially resolved light dosimetry. The MeLiDos Project anticipates advancements in wearable light metrology, paving the way for optimizing human health and well-being through wearable light logging technologies.}
@article{hartmeyer2023,
author = {Hartmeyer, S. L. and Webler, F. S. and Andersen, M.},
title = {Towards a framework for light-dosimetry studies: {Methodological} considerations},
journal = {Lighting Research \& Technology},
volume = {55},
number = {4-5},
pages = {377--399},
doi = {10.1177/14771535221103258},
year = {2023}
}

@article{zauner2023power,
title={Power analysis for personal light exposure measurements and interventions},
author={Zauner, Johannes and Udovicic, Ljiljana and Spitschan, Manuel},
year={2023},
doi={https://doi.org/10.21203/rs.3.rs-3771881/v1}
@article{lazar2024,
author = {Lazar, Rafael and Fazlali, Fatemeh and Dourte, Marine and Epple, Christian and Stefani, Oliver and Spitschan, Manuel and Cajochen, Christian},
title = {Afternoon to early evening bright light exposure reduces later melatonin production in adolescents [preprint]},
journal = {bioRxiv},
year = {2024},
doi = {10.1101/2024.10.02.616112},
url = {https://doi.org/10.1101/2024.10.02.616112}
}

@article{migueles2019,
title = {GGIR: A research community-driven open source {R} package for generating physical activity and sleep outcomes from multi-day raw accelerometer data},
author = {Migueles, Jairo H. and Rowlands, Alex V. and Huber, Florian and Sabia, Severine and van Hees, Vincent T.},
journal = {Journal for the Measurement of Physical Behavior},
volume = {2},
number = {3},
year = {2019},
doi = {10.1123/jmpb.2018-0063},
url = {https://doi.org/10.1123/jmpb.2018-0063}
}

@article{roguski2024,
author = {Roguski, A and Needham, N and MacGillivray, T and Martinovic, J and Dhillon, B and Riha, RL and Armstrong, L and Campbell, IH and Ferguson, A and Hilgen, G and Lako, M and Ritter, P and Santhi, N and von Schantz, M and Spitschan, M and Smith, DJ},
title = {Investigating light sensitivity in bipolar disorder ({HELIOS-BD})},
journal = {Wellcome Open Research},
volume = {9},
pages = {64},
doi = {10.12688/wellcomeopenres.20557.1},
pmid = {38716042},
pmcid = {PMC11074697},
month = {Feb},
year = {2024}
}

@article{spitschan2022,
author = {Spitschan, Manuel and Smolders, Karin and Vandendriessche, Benjamin and Bent, Brinnae and Bakker, Jessie P and Rodriguez-Chavez, Isaac R and Vetter, Céline},
title = {Verification, analytical validation and clinical validation ({V3}) of wearable dosimeters and light loggers},
journal = {Digital Health},
volume = {8},
pages = {20552076221144858},
doi = {10.1177/20552076221144858},
year = {2022},
month = {January}
}

@article{stefani2024,
doi = {10.20944/preprints202409.1285.v1},
url = {https://doi.org/10.20944/preprints202409.1285.v1},
year = 2024,
month = {September},
publisher = {Preprints},
author = {Oliver Stefani and Reto Marek and Jürg Schwarz and Sina Plate and Johannes Zauner and Björn Schrader},
title = {Wearable Light Loggers in Field Conditions: Corneal Light Characteristics, User Compliance and Acceptance},
journal = {Preprints}
author = {Oliver Stefani and Reto Marek and Jürg Schwarz and Sina Plate and Johannes Zauner and Björn Schrader},
title = {Wearable light Loggers in field conditions: {Corneal} light characteristics, user compliance and acceptance [preprint]},
journal = {Preprints},
doi = {10.20944/preprints202409.1285.v1},
url = {https://doi.org/10.20944/preprints202409.1285.v1},
publisher = {Preprints},
month = {September},
year = {2024}
}

@article{biller2024,
author = {Biller, Anna M. and Fatima, Nayab and Hamberger, Chrysanth and Hainke, Laura and Plankl, Verena and Nadeem, Amna and Kramer, Achim and Hecht, Martin and Spitschan, Manuel},
title = {The Ecology of Human Sleep (EcoSleep) Cohort Study: Protocol for a longitudinal repeated measurement burst design study to assess the relationship between sleep determinants and outcomes under real-world conditions across time of year},
journal = {Journal of Sleep Research},
volume = {n/a},
number = {n/a},
pages = {e14225},
keywords = {individual sleep differences, naturalistic conditions, photoperiod, prospective cohort study, season, sleep architecture, sleep variability},
doi = {https://doi.org/10.1111/jsr.14225},
url = {https://onlinelibrary.wiley.com/doi/abs/10.1111/jsr.14225},
eprint = {https://onlinelibrary.wiley.com/doi/pdf/10.1111/jsr.14225},
abstract = {Summary The interplay of daily life factors, including mood, physical activity, or light exposure, influences sleep architecture and quality. Laboratory-based studies often isolate these determinants to establish causality, thereby sacrificing ecological validity. Furthermore, little is known about time-of-year changes in sleep and circadian-related variables at high resolution, including the magnitude of individual change across time of year under real-world conditions. The Ecology of Human Sleep (EcoSleep) cohort study will investigate the combined impact of sleep determinants on individuals’ daily sleep episodes to elucidate which waking events modify sleep patterns. A second goal is to describe high-resolution individual sleep and circadian-related changes across the year to understand intra- and inter-individual variability. This study is a prospective cohort study with a measurement-burst design. Healthy adults aged 18–35 years (N = 12) will be enrolled for 12 months. Participants will continuously wear actimeters and pendant-attached light loggers. A subgroup will also measure interstitial fluid glucose levels (six paticipants). Every 4 weeks, all participants will undergo three consecutive measurement days of four ecological momentary assessments each day (‘bursts’) to sample sleep determinants during wake. Participants will also continuously wear temperature loggers (iButtons) during the bursts. Body weight will be captured before and after the bursts in the laboratory. The bursts will be separated by two at-home electroencephalogram recordings each night. Circadian phase and amplitude will be estimated during the bursts from hair follicles, and habitual melatonin onset will be derived through saliva sampling. Environmental parameters (bedroom temperature, humidity, and air pressure) will be recorded continuously.}
@article{spitschan2024,
author = {Manuel Spitschan and Johannes Zauner and Maria {Nilsson Tengelin} and Constantinos A. Bouroussis and Patrik Caspar and Fabien Eloi},
title = {Illuminating the future of wearable light metrology: Overview of the MeLiDos Project},
journal = {Measurement},
volume = {235},
pages = {114909},
doi = {10.1016/j.measurement.2024.114909},
url = {https://www.sciencedirect.com/science/article/pii/S0263224124007942},
issn = {0263-2241},
year = {2024}
}

@Book{ggplot2,
@article{wilkinson2016,
author = {Wilkinson, Mark D. and Dumontier, Michel and Aalbersberg, IJsbrand Jan and Appleton, Gabrielle and Axton, Myles and Baak, Arie and Blomberg, Niklas and Boiten, Jan-Willem and da Silva Santos, Luiz Bonino and Bourne, Philip E. and Bouwman, Jildau and Brookes, Anthony J. and Clark, Tim and Crosas, Mercè and Dillo, Ingrid and Dumon, Olivier and Edmunds, Scott and Evelo, Chris T. and Finkers, Richard and Gonzalez-Beltran, Alejandra and Gray, Alasdair J. G. and Groth, Paul and Goble, Carole and Grethe, Jeffrey S. and Heringa, Jaap and 't Hoen, Peter A. C. and Hooft, Rob and Kuhn, Tobias and Kok, Ruben and Kok, Joost and Lusher, Scott J. and Martone, Maryann E. and Mons, Barend and Packer, Abel L. and Persson, Bengt and Rocca-Serra, Philippe and Roos, Marco and van Schaik, Rene and Sansone, Susanna-Assunta and Schultes, Erik and Sengstag, Thierry and Slater, Ted and Strawn, George and Swertz, Morris A. and Thompson, Mark and van der Lei, Johan and van Mulligen, Erik and Velterop, Jan and Waagmeester, Andra and Wittenburg, Peter and Wolstencroft, Katherine and Zhao, Jun and Mons, A.},
title = {The {FAIR Guiding Principles} for scientific data management and stewardship},
journal = {Scientific Data},
volume = {3},
pages = {160018},
doi = {10.1038/sdata.2016.18},
url = {https://doi.org/10.1038/sdata.2016.18},
year = {2016}
}

@book{wickham2016,
author = {Hadley Wickham},
title = {ggplot2: Elegant Graphics for Data Analysis},
publisher = {Springer-Verlag New York},
Expand All @@ -65,35 +128,10 @@ @Book{ggplot2
url = {https://ggplot2.tidyverse.org}
}


@article{hartmeyer_towards_2023,
title = {Towards a framework for light-dosimetry studies: {Methodological} considerations:},
volume = {55},
doi = {10.1177/14771535221103258},
number = {4-5},
journal = {Lighting Research \& Technology},
author = {Hartmeyer, S. L. and Webler, F. S. and Andersen, M.},
year = {2023},
pages = {377--399},
}

@article{spitschan_verification_2022,
title = {Verification, analytical validation and clinical validation ({V3}) of wearable dosimeters and light loggers},
volume = {8},
doi = {10.1177/20552076221144858},
journal = {DIGITAL HEALTH},
author = {Spitschan, Manuel and Smolders, Karin and Vandendriessche, Benjamin and Bent, Brinnae and Bakker, Jessie P and Rodriguez-Chavez, Isaac R and Vetter, Céline},
month = jan,
year = {2022},
pages = {20552076221144858},
}

@article{de_vries_recommendations_2024,
title = {Recommendations for light-dosimetry field studies based on a meta-analysis of personal light levels of office workers},
doi = {10.1177/14771535241248540},
journal = {Lighting Research \& Technology},
author = {de Vries, SW and Gkaintatzi-Masouti, M and van Duijnhoven, J and Mardaljevic, J and Aarts, MPJ},
month = may,
year = {2024},
pages = {14771535241248540},
@article{zauner2023,
author = {Zauner, Johannes and Udovicic, Ljiljana and Spitschan, Manuel},
title = {Power analysis for personal light exposure measurements and interventions [preprint]},
journal = {Research Square},
doi = {10.21203/rs.3.rs-3771881/v1},
year = {2023}
}
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