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ToxicR 22.01 (1.0.0)
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@wheelemw wheelemw released this 28 Jan 17:44
· 412 commits to main since this release
v1.0.0
e6d6c9b

Initial Release of ToxicR 1/28/2022.

Executable files are for R 4.1.2 in Windows/Mac(Intel/M1).

  • The macOS release is single threaded due to OpenMP issues.
  • The Windows release is multi-threaded
  • For Linux compiles GSL (2.6 or greater) and NLOPT (2.4 or greater) libraries need to be installed.

Release Notes:

Dichotomous and Continuous Dose-Response functionality

Dichotomous

  • MLE functionality (Equivalent to EPA BMDS 3.x)
  • Bayesian MAP/Laplace (Equivalent to EPA BMDS 3.2+)
  • Bayesian MCMC estimates
  • Bayesian Model Averaging (MAP Equivalent to EPA BMDS 3.2+)

Continuous

  • MLE functionality (Equivalent to EPA BMDS 3.x)
  • Bayesian MAP/Laplace
  • Bayesian MCMC estimates
  • Bayesian Model Averaging

NTP Bioassay Tests

  • Dose Dependent Trend Tests (e.g. Williams etc)
  • PolyK Test

Methodologies Described in
Bailer, A.J. and Portier, C.J., 1988. Effects of treatment-induced mortality and tumor-induced mortality on tests for carcinogenicity in small
samples. Biometrics, pp.417-431.

Wheeler, M.W., Blessinger, T., Shao, K., Allen, B.C., Olszyk, L., Davis, J.A. and Gift, J.S., 2020. Quantitative Risk Assessment:
Developing a Bayesian Approach to Dichotomous Dose–Response Uncertainty. Risk Analysis, 40(9), pp.1706-1722.

Wheeler, M.W. Cortinas,J. Aerts, M. Gift, J.S. Davis J.A., 2022. Continuous Model Averaging for Benchmark Dose Analysis: Averaging Over
Distributional Forms. Resubmitted to Environmetrics.

Assets 6
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